Painful THALASSEMIA: A Review

Kaur, Rajinder and Kaur, Dilpreet (2017) Painful THALASSEMIA: A Review. Painful THALASSEMIA: A Review.

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Abstract

The term Thalassemia is a disorder, mainly prevalent among Mediterranean people, and was responsible for its naming. ‘Thalassa’ is a Greek word for the ‘Sea’, and ‘Haema’ is for ‘blood’. It was first identified by Cooley and Lee (1925), hence named ‘Cooley’ s Anaemia’. Thalassemia is an inherited blood disorder, passed down through generations through genes. The disorder is a result of the failure of formation of haemoglobin in red blood cells and consequently is causing anaemia (Forget and Cohen, 2005). Normally, red blood cells survive for 120 days but in thalassemia, red blood cell survival is reduced. Thalassemia is actually an inherited autosomal co-dominant
disorder. In this, the genetic defect results in reduced rate of synthesis of one of the globin chains that make up of haemoglobin. The most clinically relevant are alpha (á) and beta (â) thalassemias, which are caused by a mutation in globin gene cluster. These defects include mutations that usually have geographic and ethnic distribution

Item Type: Article
Uncontrolled Keywords: THALASSEMIA, Blood, Medicine
Subjects: Medicine
Curriculum Level: Senior Secondary
Depositing User: COL Staff
Date Deposited: 10 Aug 2021 17:33
Last Modified: 10 Aug 2021 17:33
URI: https://staging.oer4pacific.org/id/eprint/357

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